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The Brickner Lab studies the spatial organization of the nucleus. DNA and proteins are non-randomly localized within the nucleus. The localization of DNA, in particular, is controlled and has important effects on nuclear functions.

Current work in the lab is focused on two areas: 1) defining the molecular mechanisms by which DNA can be directed to different subnuclear environments and 2) determining the functional significance, in molecular terms, of subnuclear localization of DNA on transcription and DNA replication.