EGFR Signaling

Vn/EGFR signaling regulates Ap expression in a cell autonomous fashion only early in wing development
- ap expression partially overlaps that of vn in the second instar (Fig 4I) (Wang, 2000)
- ap can be induced ectopically in ventral clones misexpressing an activated form of the receptor, EGFR^lambdatop4.2 (Fig. 4J) (Wang, 2000)
- Egfr^tsla mutant clones generated in the first instar show autonomous loss of ap expression (Fig. 4K), whereas clones generated in the second instar express ap normally (data not shown) (Wang, 2000)
- loss of EGFR activity in whole discs from mid-first to mid-second instar (with a temperature-sensitive allele) results in complete loss of ap expression, whereas ap is still expressed in discs from larvae given a temperature shift slightly later during the second instar (Fig. 4L–N). (Wang, 2000)