Structural and functional relations of proteins and DNA, especially those pertaining to immunoglobulins and related proteins.

Our theoretical analyses of biological macromolecules may provide a unique insight into some of the fundamental problems in life sciences.

On analyzing the length distributions of the third complimentarity determining regions of human and mouse T-cell receptors for antigen gamma and delta chains in our database at http://immuno.bme.nwu.edu, we have noticed a bi-model form for delta chains.

This finding suggests that TCR gamma/delta complexes may or may not be MHC-restricted, i.e. these molecules can serve two different functions.

A novel supercoiled DNA molecule can be constructed by connecting the ends of two mutually intercalating, double-stranded, antiparallel DNA ladders. Unlike conventional supercoils, these two complementary single-stranded DNA circles can separate without any breakage of the sugar-phosphate backbone. The long-range order imposed by this structure may be the reason why many biologically active DNA molecules are intact double-stranded circles.

Journal Articles:

Johnson, G & Wu, TT (1999) Random length assortment of human and mouse T cell receptor for antigen and chain CDR3's. Immunol. Cell Biol., 77, 391-394.

Johnson, G & Wu, TT (2000) Matching amino acid and nucleotide sequences of mouse rheumatoid factor CDR3-FR4 segments to other mouse antibodies with known specificities. Bioinformatics, 16, 941-943.

Wu, TT (2001) ANALYTICAL MOLECULAR BIOLOGY, Kluwer Academic Publishers.

Wu, TT & Johnson, G (2003) Search for nearly invariant segments in HIV-1 gp120. Biophys. J.. 84, 282a.

Johnson, G & Wu, TT (2004) The Kabat database and a bioinformatics example. In ANTIBODY ENGINEERING PROTOCOLS, 2nd Ed., Ed. B. Lo, Methods Mol. Biol., 248, 11-25.

Wu, TT (1966) A model for three point analysis of random general transduction. Genetics, 54, 405-410.

Wu, TT & Kabat, EA (1970) An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J. Exp. Med., 132, 2110\-250.

Wu, TT (1978) Experimental evolution in bacteria. CRC Critical Reviews in Microbiology, pp. 33-51.

Wu, AF, Wood, C & Wu, TT (1989) Possibility of HIV gp41 and thymosin 4 sharing the same antigenic epitope. AIDS, 3, 319-320.

Wu, R & Wu, TT (1996) A novel intact circular dsDNS supercoil. Bull. Math. Biol., 58, 1171-1186.

Conference proceedings:

Wu, T.T. (1996). Novel activity of topoisomerase I, Mol. Biol. Cell 7, 101a.

Wu, T.T. (1998). Effect of glutathione on nearsightedness due to nuclear cataract, Biophys. J., 74,a370.

For additional information, visit http://myprofile.cos.com/ttwu

View all publications by publications by Tai Te Wu listed in the National Library of Medicine (PubMed).