ALL CHAPEROME PROJECT
The goal of the "All Chaperome" project is to characterize
the molecular chaperones of C. elegans. We
have identified approximately 170 chaperones corresponding
to the major classes of chaperones and co-chaperones
conserved in S. cerevisiae, and vertebrates. Taking
advantage of the lineage analysis of C. elegans,
we are determining the expression pattern of each chaperone
gene to establish a basis for network interactions and
tissue specificity during development and aging. Identification
of the chaperones expressed in specific tissues will
provide a basis for high throughput and biochemical
studies to establish the chaperone interactome. In parallel,
biochemical and biophysical studies have been initiated
to determine the structure of all members of each chaperone
family and to reconstitute chaperone-substrate interactions.
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