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Researchers in the Structural Biology, Biochemistry and Biophysics concentration
employ a wide variety of approaches to study problems in mechanistic
biology at the molecular level. Approaches that involve basic biochemistry
and proteomics to more sophisticated biophysical methods including X-ray
crystallography, solution NMR spectroscopy, electron microscopy, and
single-molecule manipulations are used to explore topics such as protein
and nucleic acid structure and function, mechanisms of gene regulation
at the transcriptional and translational levels, protein and RNA processing,
metal trafficking, and mechanisms of viral infection. Northwestern
fosters a highly collaborative environment for such multi-disciplinary
studies and provides researchers with access to outstanding research
facilities equipped with state-of-the-art instrumentation such as the
Keck Biophysics Facility and a Northwestern University dedicated beam
line at the Advanced Photon Source of the Argonne National Laboratories. The
training in this concentration is broad and consists of interdisciplinary
education through research, specialized courses in advanced topics, and
integration of several disciplines, and often involves collaborative
efforts between preceptors from various fields. Outstanding students
may be nominated for support from the Molecular Biophysics Training Grant.
Link to the Molecular Biophysics Training Program
An
informational flyer for Structural Biology, Biochemistry and Biophysics
is also available for viewing.

- Jason
Brickner, PhD: Cell biology of transcription
- Brian
M. Hoffman, PhD: Long-range interprotein electron transfer
- Linda
Hicke, PhD: Down regulation of signal transducing receptors
- Robert
A. Lamb, PhD: Viral glycoproteins, ion channels, and RNA-binding proteins
- Paul
A. Loach, PhD: Structure and function relationships in bioenergetic systems
- John
F. Marko, PhD: Protein-DNA interactions; chromosome structure and dynamics; single-molecule biophysics
- Andreas
Matouschek, PhD: Mechanisms of macromolecular machines
- Alfonso
Mondragón, PhD: DNA topoisomerases, catalytic RNA molecules, and the molecular basis of spectrin flexibility
- Richard
I. Morimoto, PhD: Regulation and function of molecular chaperones
- Thomas
V. O'Halloran, PhD: Metalloregulatory proteins
- Ishwar
Radhakrishnan, PhD: Structure, function and dynamics of proteins involved in eukaryotic gene regulation
- Amy
C. Rosenzweig, PhD: Structural biology and bioinorganic chemistry, metal uptake, transport and storage, oxygen activation by metalloenzymes, biological methane oxidation, membrane protein crystallography
- Richard
B. Silverman, PhD: Medicinal, bioorganic, and enzyme chemistry
- Erik
J. Sontheimer, PhD: Ribonucleoproteins and eukaryotic gene expression
- Olke
Uhlenbeck, PhD: RNA biochemistry
- Jonathan
Widom, PhD: Structure and function of chromosomes, biophysical chemistry of proteins and nucleic acids
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